History of Stem Cells
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- Intro to the course

  + Introduce the team
  + Before and after
  + Course mechanics
  + Topics

- Where we are today? 

  + Diabetes as an example
  + Ramzy et al Cell Stem Cell 2021

- How did we get here?

  + Stevens and Little 1954
  + 129 inbred strain of mice -> teratoma 

- What are teratomas?

- Defining properties of stem cells

- mouse embryonic stem cell derivation (Evans, Kaufman; Martin 1981)

- In vitro fertilization (Edwards 1978)

- Human embryonic stem cells (Thomson 1998)

- Cellular reprogramming (Weintraub 1986)

- Induced pluripotent stem cells (Yamanaka 2006)

- iPSCs for ...

  + disease modeling
  + drug screening

- How to guide differentiation?

- What is next?

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