ATACseq ------------------------ - DNA packaging - Various types of enzymes that cut DNA - DNase I hypersensitive sites (DHSs) - DNase profiling - ENCODE - DHS and ChIP-Seq - Mapping enhancer-to-promoter - Limitations of DNase-Seq & friends - Tn5 Transposase & ATAC-seq - Size distribution distinguishes nucleosome free from spanning - Transcription start sites (TSS) - TF fottprinting - scATAC-seq - scATAC-seq of HSPCs ----