Cell identity

• iPSC life cycle as motivating example

• Cell fate engineering

• CFE fidelity

• What is a cell type? Survey says…

• Turing test

• Functional tests

  • engraftment of HSCs

  • chimeras

• Drawbacks of functional tests

• Circuitry test

• Transcriptional state as intermediate phenotype

• Clustering

• Hierarchical

• Linkage

• Distance

• Application of clustering to iPSCs

• Decision trees

• Random forest (RF)

• RF for scRNAseq cell typing

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