History of Stem Cells

• Intro to the course

  • Introduce the team

  • Before and after

  • Course mechanics

  • Topics

• Where we are today?

  • Diabetes as an example

  • Ramzy et al Cell Stem Cell 2021

• How did we get here?

  • Stevens and Little 1954

  • 129 inbred strain of mice -> teratoma

• What are teratomas?

• Defining properties of stem cells

• mouse embryonic stem cell derivation (Evans, Kaufman; Martin 1981)

• In vitro fertilization (Edwards 1978)

• Human embryonic stem cells (Thomson 1998)

• Cellular reprogramming (Weintraub 1986)

• Induced pluripotent stem cells (Yamanaka 2006)

• iPSCs for …

  • disease modeling

  • drug screening

• How to guide differentiation?

• What is next?

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